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first_imgR&B soul-master Childish Gambino is making a quick rise in 2016. While more formally known as Donald Glover, the actor/writer/comedian/musician started as a writer for 30 Rock at the age of 23, rose to fame as the creator and star in FX’s Atlanta, and is currently cast as Lando Calrissian in Disney’s upcoming Han SoloStar Wars. But perhaps the most interesting part about this multi-skilled artist is the musical masterpiece he released earlier this month, Awaken, My Love!, which explores the future dimensions of funk, rock, and soul.Last night, he brought his #1 hit “Redbone” to The Tonight Show Starring Jimmy Fallon with a full band and stellar production. Watch the performance below:If you aren’t familiar with the new Childish Gambino record, get into it right now.last_img read more


first_imgHarvard Stem Cell Institute (HSCI) researchers at the Joslin Diabetes Center (JDC) have taken a major step toward eventually understanding — and perhaps slowing — the aging process.In a series of careful experiments, Amy J. Wagers and colleagues have demonstrated that the stem cells of old mice exposed to certain factors present in blood from young mice begin to act like young stem cells, with the process driven by signals from another type of cell nearby in the bone. In fact, not only do the blood stem cells begin to take on characteristics of younger cells, but the tissues of old mice exposed to this yet-to-be-identified factor or factors appear to be much more “youthful.This latest work by Wagers’ group is published in today’s edition of Nature. It advances the understanding of aging of the blood-forming “hematopoietic” system and points toward ways to treat age-related ailments via the blood.Doug Melton, co-director of HSCI and co-chair of Harvard’s Department of Stem Cell and Regenerative Biology called the finds “important,” explaining that “the paper shows that cells and their ‘homes,’ known as the niche, both deteriorate with age. While that may not be a surprise, what is a source of amazement is the demonstration that young animals, through the action of insulin-like growth factor 1(IGF-1), can turn back the clock and rejuvenate aged blood cells.”Previous work by other labs gave evidence that the decline in blood stem cell function that comes with age is partly intrinsic to the cells themselves. However, these cells also are affected by signals from other cells in the local bone marrow microenvironment or “niche.” An earlier study led by Shane Mayack, a postdoctoral fellow in Wagers’ lab, pinpointed bone-forming cells known as osteoblasts as key players in this signaling from the niche, and showed that osteoblasts play a particular role in blood stem cell maintenance and regeneration.For the latest paper, Mayack and her colleagues studied the blood stem cell aging process in young and old mice. The researchers found that as osteoblasts age, they change the signals that they send to stem cells, and that this change makes those cells less able to produce the right mixture of blood cells.More dramatically, in a series of tests in which two mice shared a common blood circulation, the scientists revealed that this aging mechanism could be reversed. In old mice paired with young mice, the existing populations of osteoblasts showed signs of rejuvenation. Remarkably, this rejuvenation was communicated to the stem cells as well, such that the blood-forming abilities of these aged mice took on much more “youthful” characteristics.“What’s most exciting is that the changes that occur in blood stem cells during aging are reversible, through signals carried by the blood itself,” said Wagers, an associate professor in Harvard’s Department of Stem Cell and Regenerative Biology, HSCI Principal Faculty member, and an investigator at the Joslin. “This means that the blood system offers a potential therapeutic avenue for age-related stem cell dysfunction.”“These findings open up exciting new avenues of research, including the potential for studying other types of tissues that aren’t as well understood, in which aging may be regulated by stem-niche cell interactions in a similar way,” said Mayack. “Over time, these findings may also influence the way blood disorders are treated.”As a next step, investigators will hone in on how signals sent to and from osteoblasts are altered as the cells age. The Joslin team has begun by examining the role of IGF-1, a protein that other studies have shown can aid in regenerating skeletal muscle. To their surprise, they found that they could partially correct aging defects in osteoblasts by suppressing IGF-1, rather than enhancing it. “This difference highlights the complexity of the controls that are involved in cell regeneration,” Wagers said.While the work does not directly address diabetes mechanisms, Wagers, a Howard Hughes Medical Institute Early Career Scientist, noted that “there’s more and more evidence of an overlap in the regulatory pathways that are implicated in aging and in type 2 diabetes.”Jennifer L. Shadrach and Francis S. Kim, both of Joslin, also contributed to the project. The work was supported by the National Institutes of Health, the Burroughs Wellcome Fund, the Glenn Foundation, the Iacocca Foundation, the W.M. Keck Foundation, and the Howard Hughes Medical Institute.last_img read more


first_imgWe are poised to take digital transformation to the next level, and I’m honored to be Dell’s new Chief Digital Officer to further hone and strengthen our engagement with business partners, cultivate a strong engineering and operational discipline and culture, and lead with simplicity and accountability. The role combines the traditional roles and responsibilities of a CIO along with the emerging role of change agent for digital transformation. It reminds me and my whole organization that we are a key enabler for digital transformation and much more than “keeping the lights on.”The Path to DigitalFor companies that didn’t grow up completely digital, redefining and automating processes to improve operations often aren’t enough. We must also create compelling and efficient experiences for our customers and team members. This often requires us to transform our traditional processes into digital processes, where there are no delays due to manual intervention, batch processes or legacy infrastructure.The destination is clear, but the path to get there isn’t easy. Over the past couple of years, our Dell Digital team, which is the evolution of our IT organization, has been on a path to modernize our own processes and technology, while investing in our team with new skills and ways of working to address this challenge.We call the combination the Dell Digital Way, and the goal is to both digitally transform our IT processes and to enable our business partners to do the same. We’re working in balanced teams, with developers side by side with our business partners, and leveraging our DevOps and private cloud technology and practices. A modern way of working is what Dell Technologies’ products and solutions enable for our customers and what we want to experience in our own work here at Dell.The Next Phase of Our Digital JourneyWe are headed in the right direction with our IT transformation, and the next phase of this journey will be moving forward with our product-oriented approach that will drive more direct accountability for how our solutions are designed and operate. We’re moving Design and DevOps to the forefront of IT, like a software organization. With a better understanding of our customers’ and partners’ needs, we can more quickly adapt and introduce new capabilities to improve the overall experience. All of this relies on our continued work to modernize our applications and infrastructure by migrating to our private/hybrid cloud.A unique aspect of our new operating model is that it features four critical cross-functional journeys aligned to the experiences that people have with us. These are the Customer journey, Team Member journey, Product Group Enablement journey, and Product journey, which is the experience for our own organization to design, develop and deploy solutions. Members of my leadership team will assume responsibility for these journeys to drive focus, accountability and progress across the functional operations.As we drive our strategy from the perspective of the customer experience and operational excellence, I’m confident we have the right people, processes and technology to level up our digital transformation and improve the way we work.last_img read more


first_imgThe Vatican said Tuesday it was closing Saint Peter’s Square and its main basilica to tourists — but not the faithful — as part of a broader clampdown to curb the coronavirus The Holy See said the measures will remain in place until April 3 “to halt the spread of the coronavirus”.The announcement sparked a wave of confusion because churches are supposed to remain open across Italy as a whole during the country’s month-long ban on public gatherings. Pope Francis himself was forced to break with centuries of tradition and deliver his Sunday Angelus Prayer via livestream instead of from his Vatican window to limit crowds on Saint Peter’s Square.Saint Peter’s basilica is one of the world’s most popular tourist attractions. Its dome — the tallest in the world — soars over Rome and is visible across the Italian capital.It is filled with frescos and statues by great Renaissance masters such as Michelangelo. ‘Go out and see’ The 83-old-pontiff is still recovering from a cold he developed about two weeks ago.He spoke with a slight rasp in on Tuesday during a morning prayer in which he urged priests across the world to go out and meet those suffering from the new disease.”Let us pray to the Lord also for our priests, may they have the courage to go out and see the sick, bringing them the strength of the word of God and the Eucharist, and accompany health workers and volunteers in the work they do,” the pope said a video from his residence in the Vatican.He bowed carefully and gingerly kissed the bible before delivering the prayer.”Let us continue to pray together for the sick, the health workers, so many people who are suffering because of this epidemic,” he said.The Argentine-born pope has enjoyed a life of good health and follows a rigorous schedule despite having a part of a lung removed when he was young.His unusual absence during the coronavirus scare prompted immediate speculation that he had contracted COVID-19.A newspaper reported last week that the pope had been tested for the virus but was not infected.The Vatican neither confirmed nor denied the report.Topics : A Vatican source later clarified to AFP that anyone who expresses a wish to pray at the basilica can still pass through the police barrier and walk onto the main square.Italy’s new nationwide restrictions on social events and travel are designed to curb the spread of a disease that has killed 631 and infected 10,149 in just over two weeks.The Vatican has so far officially confirmed one case of the COVID-19 disease caused by the new virus that was detected in a person who was using one of its public pharmacies.It was also awaiting the results of a second person who came in contact with a virus carrier at an event organised by the Vatican at the start of the month.last_img read more