Harvard Stem Cell Institute (HSCI) researchers at the Joslin Diabetes Center (JDC) have taken a major step toward eventually understanding — and perhaps slowing — the aging process.In a series of careful experiments, Amy J. Wagers and colleagues have demonstrated that the stem cells of old mice exposed to certain factors present in blood from young mice begin to act like young stem cells, with the process driven by signals from another type of cell nearby in the bone. In fact, not only do the blood stem cells begin to take on characteristics of younger cells, but the tissues of old mice exposed to this yet-to-be-identified factor or factors appear to be much more “youthful.This latest work by Wagers’ group is published in today’s edition of Nature. It advances the understanding of aging of the blood-forming “hematopoietic” system and points toward ways to treat age-related ailments via the blood.Doug Melton, co-director of HSCI and co-chair of Harvard’s Department of Stem Cell and Regenerative Biology called the finds “important,” explaining that “the paper shows that cells and their ‘homes,’ known as the niche, both deteriorate with age. While that may not be a surprise, what is a source of amazement is the demonstration that young animals, through the action of insulin-like growth factor 1(IGF-1), can turn back the clock and rejuvenate aged blood cells.”Previous work by other labs gave evidence that the decline in blood stem cell function that comes with age is partly intrinsic to the cells themselves. However, these cells also are affected by signals from other cells in the local bone marrow microenvironment or “niche.” An earlier study led by Shane Mayack, a postdoctoral fellow in Wagers’ lab, pinpointed bone-forming cells known as osteoblasts as key players in this signaling from the niche, and showed that osteoblasts play a particular role in blood stem cell maintenance and regeneration.For the latest paper, Mayack and her colleagues studied the blood stem cell aging process in young and old mice. The researchers found that as osteoblasts age, they change the signals that they send to stem cells, and that this change makes those cells less able to produce the right mixture of blood cells.More dramatically, in a series of tests in which two mice shared a common blood circulation, the scientists revealed that this aging mechanism could be reversed. In old mice paired with young mice, the existing populations of osteoblasts showed signs of rejuvenation. Remarkably, this rejuvenation was communicated to the stem cells as well, such that the blood-forming abilities of these aged mice took on much more “youthful” characteristics.“What’s most exciting is that the changes that occur in blood stem cells during aging are reversible, through signals carried by the blood itself,” said Wagers, an associate professor in Harvard’s Department of Stem Cell and Regenerative Biology, HSCI Principal Faculty member, and an investigator at the Joslin. “This means that the blood system offers a potential therapeutic avenue for age-related stem cell dysfunction.”“These findings open up exciting new avenues of research, including the potential for studying other types of tissues that aren’t as well understood, in which aging may be regulated by stem-niche cell interactions in a similar way,” said Mayack. “Over time, these findings may also influence the way blood disorders are treated.”As a next step, investigators will hone in on how signals sent to and from osteoblasts are altered as the cells age. The Joslin team has begun by examining the role of IGF-1, a protein that other studies have shown can aid in regenerating skeletal muscle. To their surprise, they found that they could partially correct aging defects in osteoblasts by suppressing IGF-1, rather than enhancing it. “This difference highlights the complexity of the controls that are involved in cell regeneration,” Wagers said.While the work does not directly address diabetes mechanisms, Wagers, a Howard Hughes Medical Institute Early Career Scientist, noted that “there’s more and more evidence of an overlap in the regulatory pathways that are implicated in aging and in type 2 diabetes.”Jennifer L. Shadrach and Francis S. Kim, both of Joslin, also contributed to the project. The work was supported by the National Institutes of Health, the Burroughs Wellcome Fund, the Glenn Foundation, the Iacocca Foundation, the W.M. Keck Foundation, and the Howard Hughes Medical Institute.
September 20, 2020
The family of teenager at the center of the video that shows a Broward Sheriff’s deputy slamming his head on the ground in front of a crowd of high school students in Tamarac is speaking out for the first time.His mother Clintina Rolle spoke with NBC6https://www.850wftl.com/wp-content/uploads/2019/04/Mother-of-roughed-up-teen.mp3The video of the rough arrest of 15 year-old Delucca Rolle has since gone viral.Broward Sheriff Gregory Tony is asking the public to not judge his deputies until the investigation into the case is complete saying they deserve due process.Also, that the incident may have simply been a de-escalation technique.https://www.850wftl.com/wp-content/uploads/2019/04/Gregory-Tony.mp3Deputy Christopher Krickovich and Sgt. Gregory LaCerra have been suspended with pay pending the outcome of an internal investigation.Sheriff Tony says he does not agree with the Broward State Attorney’s Office dropping all the charges against the teen.Rolle was initially arrested on charges of assaulting a law enforcement officer, resisting arrest and trespassing. Prominent civil rights attorney Ben Crump held a news conference Thursday to discuss the treatment of a teenager whose rough arrest by Broward Sheriff’s Office deputies has gained national attention.Crump and the NAACP are getting involved in the treatment of Delucca Rolle, who was pepper sprayed, thrown to the ground and punched by deputies April 18 outside a McDonald’s in Tamarac. Sheriff Gregory Tony is calling for due process for the suspended deputies involved in the incident.Crump, however, said the video clearly shows that the deputies were in the wrong.“They were not acting like responsible professionals with proper training, following procedures,” he said.
September 18, 2020
The Ministry of Youth and Sports is to provide lighting and equipment for para-table tennis athletes training at the National Stadium Surulere Lagos, ahead of the Rio Olympic Games.The Minister of Youth and Sports, Solomon Dalung, gave the assurance when he visited the para- table tennis athletes currently camping at the Brai Ayonote Hostel at the National Stadium, Lagos.One of the athletes, Faith Obiora, complained of poor lighting at the training venue, leaking roofs as well as inadequate equipment.Dalung however promised the athletes that he will give immediate attention to the provision of equipment and lighting while the ministry will also fix the leaking roofs as soon as possible.“We are training against time because the Olympics is fast approaching. Although we haven’t been able to do much due to paucity of funds, we will do those things that need urgent attention. I have already directed that equipment for training should be acquired and it is expected that they’ll be available soon,” observed the minister.He charged the athletes to take their training programme seriously as the Olympics will be a battle ground for world champions.“Having qualified, you need to train very well because you’re going to face other qualifiers. Do your best in training and aspire to dominate your opponents during the games”.Super heavy weight boxer, Efe Ajagba, the only boxer to have qualified so far for the Olympics also proposed a training tour to enhance his skills. He complained of the poor state of the boxing ring and the floor of the gymnasium.The minister however assured him and other athletes that the next stage of camping will be outside the country. “Our camping will be in two phases. Since we’ve not been able to improve on our facilities, we will make use of what we have for the first stage which will soon be over before exposing you to the second phase which will be outside the country.“I believe that the state of our facilities will be better before the next Olympics. Do not be discouraged because all your sacrifices are for the country. I wish you well and we will consider training tours that will be of comparative advantage to all athletes,” Dalung assured the athletes.The minister had a fortnight ago visited athletes in camp during training at the Abuja National Stadium. They are para athletics, power-lifting , wrestling, weightlifting and athletics.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram