Governmental Measures Target Expanded Access to Affordable Housing 2 days ago Print This Post Previous: How Could Import Tariffs Affect Housing? Next: Lee Wardlow to Lead Loan Servicing at BOK Financial Mortgage The Week Ahead: Federal Reserve Releases New Beige Book March 4, 2018 2,445 Views With a newly installed Fed Chair in the form of Jerome Powell and analysts watching closely to track the impacts of things like tax reform and interest rate policy, all eyes are on the Fed as we approach the next meeting of the Federal Open Market Committee on March 20-21. Before the FOMC meeting, however, comes the Beige Book.The Federal Reserve will release its latest Beige Book on this coming Wednesday, March 6, at 2 p.m. EST. The Beige Book presents a summary of economic conditions and activity, based on reports from the various Fed district banks. It’s an early glimpse at the conditions the Fed is tracking and considering and serves as a sort of first look at what may be discussed at the FOMC meeting that follows a few weeks thereafter. The Fed is widely expected to raise interest rates again at this next FOMC meeting, but the Beige Book may also provide further insights into what will come out of that next gathering.Here’s what else is happening in The Week Ahead:MBA Mortgage Apps, Wednesday, 7 a.m. ESTADP Employment Report, Wednesday, 8:15 a.m. ESTConsumer Credit Report, Wednesday, 3 p.m. ESTJobless Claims, Thursday, 8:30 a.m. ESTFed Balance Sheet, Thursday, 4:30 p.m. ESTFreddie Mac Primary Mortgage Market Survey, Thursday, 9 a.m. EST Demand Propels Home Prices Upward 2 days ago Governmental Measures Target Expanded Access to Affordable Housing 2 days ago Servicers Navigate the Post-Pandemic World 2 days ago Beige Book Federal Reserve the week ahead 2018-03-04 David Wharton The Best Markets For Residential Property Investors 2 days ago Share Save Tagged with: Beige Book Federal Reserve the week ahead About Author: David Wharton Data Provider Black Knight to Acquire Top of Mind 2 days ago Demand Propels Home Prices Upward 2 days ago in Daily Dose, Featured, Headlines, Journal, Market Studies, News Home / Daily Dose / The Week Ahead: Federal Reserve Releases New Beige Book The Best Markets For Residential Property Investors 2 days ago Related Articles Servicers Navigate the Post-Pandemic World 2 days ago Data Provider Black Knight to Acquire Top of Mind 2 days ago The Week Ahead: Nearing the Forbearance Exit 2 days ago Sign up for DS News Daily Subscribe
March 1, 2021
Harvard Stem Cell Institute (HSCI) researchers at the Joslin Diabetes Center (JDC) have taken a major step toward eventually understanding — and perhaps slowing — the aging process.In a series of careful experiments, Amy J. Wagers and colleagues have demonstrated that the stem cells of old mice exposed to certain factors present in blood from young mice begin to act like young stem cells, with the process driven by signals from another type of cell nearby in the bone. In fact, not only do the blood stem cells begin to take on characteristics of younger cells, but the tissues of old mice exposed to this yet-to-be-identified factor or factors appear to be much more “youthful.This latest work by Wagers’ group is published in today’s edition of Nature. It advances the understanding of aging of the blood-forming “hematopoietic” system and points toward ways to treat age-related ailments via the blood.Doug Melton, co-director of HSCI and co-chair of Harvard’s Department of Stem Cell and Regenerative Biology called the finds “important,” explaining that “the paper shows that cells and their ‘homes,’ known as the niche, both deteriorate with age. While that may not be a surprise, what is a source of amazement is the demonstration that young animals, through the action of insulin-like growth factor 1(IGF-1), can turn back the clock and rejuvenate aged blood cells.”Previous work by other labs gave evidence that the decline in blood stem cell function that comes with age is partly intrinsic to the cells themselves. However, these cells also are affected by signals from other cells in the local bone marrow microenvironment or “niche.” An earlier study led by Shane Mayack, a postdoctoral fellow in Wagers’ lab, pinpointed bone-forming cells known as osteoblasts as key players in this signaling from the niche, and showed that osteoblasts play a particular role in blood stem cell maintenance and regeneration.For the latest paper, Mayack and her colleagues studied the blood stem cell aging process in young and old mice. The researchers found that as osteoblasts age, they change the signals that they send to stem cells, and that this change makes those cells less able to produce the right mixture of blood cells.More dramatically, in a series of tests in which two mice shared a common blood circulation, the scientists revealed that this aging mechanism could be reversed. In old mice paired with young mice, the existing populations of osteoblasts showed signs of rejuvenation. Remarkably, this rejuvenation was communicated to the stem cells as well, such that the blood-forming abilities of these aged mice took on much more “youthful” characteristics.“What’s most exciting is that the changes that occur in blood stem cells during aging are reversible, through signals carried by the blood itself,” said Wagers, an associate professor in Harvard’s Department of Stem Cell and Regenerative Biology, HSCI Principal Faculty member, and an investigator at the Joslin. “This means that the blood system offers a potential therapeutic avenue for age-related stem cell dysfunction.”“These findings open up exciting new avenues of research, including the potential for studying other types of tissues that aren’t as well understood, in which aging may be regulated by stem-niche cell interactions in a similar way,” said Mayack. “Over time, these findings may also influence the way blood disorders are treated.”As a next step, investigators will hone in on how signals sent to and from osteoblasts are altered as the cells age. The Joslin team has begun by examining the role of IGF-1, a protein that other studies have shown can aid in regenerating skeletal muscle. To their surprise, they found that they could partially correct aging defects in osteoblasts by suppressing IGF-1, rather than enhancing it. “This difference highlights the complexity of the controls that are involved in cell regeneration,” Wagers said.While the work does not directly address diabetes mechanisms, Wagers, a Howard Hughes Medical Institute Early Career Scientist, noted that “there’s more and more evidence of an overlap in the regulatory pathways that are implicated in aging and in type 2 diabetes.”Jennifer L. Shadrach and Francis S. Kim, both of Joslin, also contributed to the project. The work was supported by the National Institutes of Health, the Burroughs Wellcome Fund, the Glenn Foundation, the Iacocca Foundation, the W.M. Keck Foundation, and the Howard Hughes Medical Institute.
January 18, 2021
Show Closed This production ended its run on Jan. 24, 2016 View Comments The Broadway.com staff is crazy for Culturalist, the website that lets you choose and create your own top 10 lists. Every week, we’re challenging you with a new Broadway-themed topic to rank. With the Deaf West production of Duncan Sheik and Steven Sater’s Tony-winnning Spring Awakening gearing up for a September opening, we’ve been listening to the rocking score on repeat. There. Are. So. Many. Good. Songs. So we must know: How would you rank your top 10 songs in Spring Awakening? Broadway.com Site Producer Joanne Villani kicked off this new challenge with her list of top 10 picks here!STEP 1—SELECT: Visit Culturalist to see all of your options. Highlight your 10 favorites and click the “continue” button.STEP 2—RANK: Reorder your 10 choices by dragging them into the correct spot on your list. Click the “continue” button.STEP 3—PREVIEW: You will now see your complete top 10 list. If you like it, click the “publish” button.Once your list is published, you can see the overall rankings of everyone on the aggregate list.Pick your favorites, then tune in for the results next week on Broadway.com! Related Shows Spring Awakening
September 28, 2020
Smulders UK is in discussions with the UK government over internships and apprenticeships that would increase the local labour and the company is especially focusing on skilled welders, who are a critical element in the production sequence. Majority of welders are local, but the company is currently also employing people from Europe since it could not find sufficient number of welders in the UK, according to Tom Coosemans, General Manager of Smulders UK.One of the main reasons Smulders set up a UK facility is that in the near future there will be a lot of projects in the country and the company already has a vast track record of projects done in the UK, Coosemans said.Smulders is now working, among others, on the foundations for the Aberdeen Bay offshore wind farm. In Belgium, the company is well ahead with the upper parts of the jackets and has recently started receiving material for the lower parts of the jackets. The suction buckets were expected to arrive at the end of June.Find out more about Smulders, its UK business and projects, as well as the cooperation with Sif Group in our Expertise Hub interview, recorded at the beginning of June in London. For more Expertise Hub interviews, visit Navingo’s Offshore WIND channel on Vimeo.
September 28, 2020
Marine fuel supplier ScanOcean has signed an agreement with Finland-based oil refining company Neste to resell fuel on the East Coast of Sweden.Under the cooperation deal, ScanOcean would deliver Neste’s 0.1% marine fuel products to the region.Neste supplies from its terminal in Södertälje service nearby ports from Gävle in the north to Norrköping in the south and Lake Mälaren. Neste’s marine fuels are available at all Finnish ports and through ScanOcean cooperation now in the greater Stockholm area.“We are excited to increase our product offering and to further promote Neste’s unique marine fuels to the Swedish market by showing our clients the benefits of the DMB and RMB products compared to other marine fuels,” Jonatan Karlström, General manager at ScanOcean, said.
September 16, 2020
Facebook Twitter Google+ Related Stories Live blog: Syracuse holds on to beat Connecticut, 31-24 Comments Published on September 24, 2016 at 3:26 pm Contact Tony: [email protected]