Harvard Stem Cell Institute (HSCI) researchers at the Joslin Diabetes Center (JDC) have taken a major step toward eventually understanding — and perhaps slowing — the aging process.In a series of careful experiments, Amy J. Wagers and colleagues have demonstrated that the stem cells of old mice exposed to certain factors present in blood from young mice begin to act like young stem cells, with the process driven by signals from another type of cell nearby in the bone. In fact, not only do the blood stem cells begin to take on characteristics of younger cells, but the tissues of old mice exposed to this yet-to-be-identified factor or factors appear to be much more “youthful.This latest work by Wagers’ group is published in today’s edition of Nature. It advances the understanding of aging of the blood-forming “hematopoietic” system and points toward ways to treat age-related ailments via the blood.Doug Melton, co-director of HSCI and co-chair of Harvard’s Department of Stem Cell and Regenerative Biology called the finds “important,” explaining that “the paper shows that cells and their ‘homes,’ known as the niche, both deteriorate with age. While that may not be a surprise, what is a source of amazement is the demonstration that young animals, through the action of insulin-like growth factor 1(IGF-1), can turn back the clock and rejuvenate aged blood cells.”Previous work by other labs gave evidence that the decline in blood stem cell function that comes with age is partly intrinsic to the cells themselves. However, these cells also are affected by signals from other cells in the local bone marrow microenvironment or “niche.” An earlier study led by Shane Mayack, a postdoctoral fellow in Wagers’ lab, pinpointed bone-forming cells known as osteoblasts as key players in this signaling from the niche, and showed that osteoblasts play a particular role in blood stem cell maintenance and regeneration.For the latest paper, Mayack and her colleagues studied the blood stem cell aging process in young and old mice. The researchers found that as osteoblasts age, they change the signals that they send to stem cells, and that this change makes those cells less able to produce the right mixture of blood cells.More dramatically, in a series of tests in which two mice shared a common blood circulation, the scientists revealed that this aging mechanism could be reversed. In old mice paired with young mice, the existing populations of osteoblasts showed signs of rejuvenation. Remarkably, this rejuvenation was communicated to the stem cells as well, such that the blood-forming abilities of these aged mice took on much more “youthful” characteristics.“What’s most exciting is that the changes that occur in blood stem cells during aging are reversible, through signals carried by the blood itself,” said Wagers, an associate professor in Harvard’s Department of Stem Cell and Regenerative Biology, HSCI Principal Faculty member, and an investigator at the Joslin. “This means that the blood system offers a potential therapeutic avenue for age-related stem cell dysfunction.”“These findings open up exciting new avenues of research, including the potential for studying other types of tissues that aren’t as well understood, in which aging may be regulated by stem-niche cell interactions in a similar way,” said Mayack. “Over time, these findings may also influence the way blood disorders are treated.”As a next step, investigators will hone in on how signals sent to and from osteoblasts are altered as the cells age. The Joslin team has begun by examining the role of IGF-1, a protein that other studies have shown can aid in regenerating skeletal muscle. To their surprise, they found that they could partially correct aging defects in osteoblasts by suppressing IGF-1, rather than enhancing it. “This difference highlights the complexity of the controls that are involved in cell regeneration,” Wagers said.While the work does not directly address diabetes mechanisms, Wagers, a Howard Hughes Medical Institute Early Career Scientist, noted that “there’s more and more evidence of an overlap in the regulatory pathways that are implicated in aging and in type 2 diabetes.”Jennifer L. Shadrach and Francis S. Kim, both of Joslin, also contributed to the project. The work was supported by the National Institutes of Health, the Burroughs Wellcome Fund, the Glenn Foundation, the Iacocca Foundation, the W.M. Keck Foundation, and the Howard Hughes Medical Institute.
January 26, 2021
On Monday evening, Saint Mary’s alumnae Liz Palmer ‘13, Malea Schulte ’14 and co-travelers Jonathan and Tameka Bell shared the lessons they learned from spending two weeks in Rwanda this past summer in a presentation titled “Project Rwanda: A Journey in Solidarity.” Caitlyn Jordan Saint Mary’s alumna Malea Schulte ’14 delivers presentation Monday evening on her experience in Rwanda working with both victims and perpetrators of the Rwandan genocide.In the Rwandans they met, Palmer and Schulte saw strength and faith resonating in the aftermath of the 1994 genocide, Palmer said.In 1994, over one million Tutsi Rwandans were killed in a 100-day period. During this genocide, one out of every 10 Tutsi Rwandans were killed, Palmer said.“In recognition of 20 years post-genocide, Malea and I were driven by Saint Mary’s core values of faith and spirituality, community learning and justice to embark on this mission of solidarity … simply to hear the stories of the people,” Palmer said. “We were looking to highlight our shared humanity and weave into the fabric of our culture that every single life matters.”The project began as part two of Malea’s senior composition titled “Storybank,” which included 26 portraits depicting a cross section of the Saint Mary’s community, Schulte said.“One of the participants was a woman from Rwanda whose story inspired me to journey to her home country with the goal of learning through listening and sharing through art,” Schulte said.Before journeying to Rwanda, Schulte and Palmer partnered with People Improving Communities through Organizing (PICO), an international, faith-based, non-governmental organization committed to stimulating communal growth through organization, Schulte said.“Together we formed a delegation of 20 people, and it included Catholic priests, Lutheran priests, writers, storytellers, professors and artists,” Schulte said.Two members of the delegation were Jonathan Bell, a senior communications advisor to PICO-Rwanda, and Tameka Bell, a story and communications trainer for PICO’s international network, Schulte said.With pictures taken by Jonathan Bell hanging in the gallery, Tameka Bell shared her experience during the presentation. In Rwanda, she witnessed community building in numerous lives, including when a woman died while giving birth during a long walk to the nearest hospital, she said. A few days after the woman’s death, a much-needed clinic and road was finally completed as a result of community organizing.“When one person tells a story to another person, they can change the world,” Tameka Bell said. “That’s really at the center of community organizing.”A meeting with the vice president of Rwanda’s senate inspired the group to share the story of their time in Rwanda with others, Tameka Bell said.“He said to us, ‘When you go back to the United States, would you tell them who we really are? Ask them not to judge us by the worst day of our life. Ask them to see the whole person, the whole community — the joy and the sorrow and the laughter and the innocence — who we really are,’” Tameka Bell said.Rwandans have worked for reconciliation and forgiveness in the aftermath of the genocide, Schulte said. The Gacaca courts facilitated healing by allowing perpetrators a chance to confess and ask for forgiveness, she said.“We witnessed victims and perpetrators working together in harmony,” Schulte said. “We visited a women’s vegetable cooperative where perpetrators and victims were working together to support themselves. … It was very clear they worked with a sense of pride and towards the common good.”In interacting with Rwandans, Palmer and Schulte initiated conversation with the question, “How do you want to be remembered?” The variety of answers to that question, such as ‘I pray,’ was life changing, Palmer said.During their time in Rwanda, Schulte and Palmer lived by the saying ‘We don’t wait for road to be built; we build them ourselves,’ a quote adopted from Pastor John, a friend made in Rwanda, Palmer said. Both learned about the world and themselves and how to grasp every moment of life.“Time is money, and we don’t know how much time we do have, and that’s one thing the Rwandans definitely made clear,” Palmer said. “And yet they live every day to the fullest. I think life is a series of single moments, and we need to grasp that.”Sophomore Lauren Zyber said she thought the presentation was incredible, and she was moved when an audio of Schulte and several other Rwandans spontaneously singing Amazing Grace was played.“I thought it was amazing to see how much this experience had impacted them and the stories that they told,” Zyber said. “… The power of stories is incredible to me.”Tags: jonathan bell, liz palmer, malea schulte, PICO, project rwanda: a journey in solidarity, Rwanda, rwanda project, Rwandan Genocide, storybank, tameka bell
November 20, 2020
– Advertisement – The Geekbench listing was first spotted by 91Mobiles and independently verified by Gadgets 360.Back in August, a report suggested that the rumoured Samsung Galaxy A12 will have a 32GB and a 64GB storage model, with 3GB of RAM. There could be another RAM variant as well. It was also said that the phone will carry the same LCD display as well as the triple rear camera system present in Galaxy A11, but may come with a larger battery. The report also claimed that the Galaxy A12 could be offered in black, blue, red, and white colour options.Earlier this month, a report by MySmartPrice stated that the Galaxy A12 was spotted on the NFC certification website, suggesting that it could come with NFC support as well.- Advertisement – As of now, Samsung has not shared any information on the Galaxy A12 and it’s unclear when the phone will be launched.Which is the best TV under Rs. 25,000? We discussed this on Orbital, our weekly technology podcast, which you can subscribe to via Apple Podcasts, Google Podcasts, or RSS, download the episode, or just hit the play button below. – Advertisement – Samsung Galaxy A12 has been reportedly spotted on Geekbench with model number SM-A125F. The phone will be a follow up to Samsung Galaxy A11 that was launched in May this year. The Geekbench listing for Samsung Galaxy A12 shows a 3GB RAM variant that is powered by the MediaTek Helio P35 (MT6765) SoC. The phone first came under the spotlight back in August and at the time, it was speculated that it could come with two storage options and a triple rear camera setup.The Geekbench listing shows a Samsung phone with model number SM-A125F, believed to be Samsung Galaxy A12. It runs on Android 10 and is powered by the octa-core MediaTek Helio P35 (MT6765) SoC. The phone is listed with 3GB RAM. No other RAM variants were mentioned. The purported Galaxy A12 scored 169 in single-core and 1,001 in multi-core benchmarks.- Advertisement –
October 20, 2020
Categories: Letters to the Editor, OpinionAfter one year in business, the Rivers Casino results aren’t as good as expected.As a customer, it’s obvious to me some of the things they could do to increase business. They need to make their casino more user friendly. They need many more handicapped parking spaces. They don’t need the noise from the PA system. They don’t have to overcharge for food and drinks.Drinks are traditionally free in gambling casinos — the word is they are in the new Catskill casino.I think that if some of these suggestions are implemented, customers would feel more welcome and business would increase.Tom SingerDelansonMore from The Daily Gazette:Schenectady County warns of possible COVID-19 exposure at Schenectady restaurant, Rotterdam barEDITORIAL: Thruway tax unfair to working motoristsEDITORIAL: Beware of voter intimidationEDITORIAL: Urgent: Today is the last day to complete the censusEDITORIAL: Find a way to get family members into nursing homes
October 19, 2020
But copies of the emergency regulations leaked to Israeli media showed that police would be able to retrieve location data of coronavirus carriers — as well as quarantined people — from phone companies, without a court order.The Shin Bet would also be able to use the location data of coronavirus carriers for the 14 days preceding their diagnosis “to identify their routes and the people with whom they came in contact with,” the leaked material said. The government “authorized the Shin Bet to put its advanced technologies in the service of the national effort to reduce the spread of coronavirus,” a Shin Bet statement said Tuesday.A Shin Bet spokesperson separately told AFP that the policy has taken “immediate” effect. “The Shin Bet is aware this is a task that goes beyond its routine anti-terror activities,” Shin Bet chief Nadav Argaman said in the agency’s statement, adding that “oversight and regulating mechanisms” had been established. Prime Minister Benjamin Netanyahu’s office refused to provide details about the monitoring techniques to be used. Israel’s internal security agency Shin Bet said Tuesday it has been mandated to collect information about citizens to fight the spread of the deadly coronavirus, a task it was undertaking with “immediate” effect.Involvement of the spy agency in tackling the pandemic has raised concerns about adherence to democratic norms, with one legal expert fearing it harms “trust and legitimacy” and an analyst describing it as a “dangerous precedent”.The measure was approved by the government under emergency regulations, overriding a parliamentary committee that on Monday had withheld final approval, saying it needed more time to ensure proper safeguarding. ‘Cloak & dagger’ Argaman said the information would be given to the health ministry and not stored by the Shin Bet. Gabi Ashkenazi, who heads the parliamentary committee that withheld approval, said Tuesday that using Shin Bet against the virus was not appropriate “without parliamentary and public supervision.”Ashkenazi, a member of the Blue and White coalition that rivals Netanyahu’s Likud party, called for a new foreign and defence committee to “implement the supervision necessary by law.”Netanyahu’s cabinet had approved the move at his behest on Sunday, before it moved to parliament for consideration.Netanyahu defended his later emergency move, saying that “even an hour’s delay using these tools could lead to the death of many Israelis”.In a statement, the premier’s office also claimed parliamentary deliberations could have taken “many days.”He and his attorney general therefore “swiftly” approved the emergency measures that are valid for 14 days, during which time lawmakers can express their reservations. Michael Birnhack, a law professor at Tel Aviv University, said the coronavirus crisis has been steered into a security issue.”Instead of trust and solidarity [‘do you agree we check your location?’] we’ve gone into cloak and dagger, suspicion lack of trust,” he wrote on Twitter.”It might be efficient but it harms trust and legitimacy,” he said. “The intentions here are good, but the path is problematic. The fear is this will remain long after the crisis is over.”Speaking before the emergency regulations, Tehilla Shwartz Altshuler of the Israel Democracy Institute (IDI) said involving Shin Bet would set “a dangerous precedent” that risked being a precursor to interventions in other sectors.A security official told AFP on Monday the Shin Bet would not conduct “active penetration into phones” and “there won’t be cyber-attacks.”Netanyahu’s continued tenure as premier is uncertain, with President Reuven Rivlin on Monday formally handing centrist rival Benny Gantz a mandate to try to form a new government.Gantz has been given 28 days to put together a coalition, after he garnered recommendations from 61 out of 120 lawmakers on Sunday, in the wake of an election held on March 2 – Israel’s third national polls within a year. Topics :
October 19, 2020
“Starting from July, we will focus on the recovery of aviation traffic to support economic activities in Indonesia,” said Awaluddin in an official statement on July 4.The plan is part of the company’s strategy to ignite the recovery of the aviation industry, which also includes reopening domestic routes and increasing flight frequency.The aviation industry has been battered by the COVID-19 outbreak, as people have been forced to cancel their travel plans amid restrictions on movement. The International Air Transport Association (IATA) has stated that 2020 will be the worst year in history for airlines, with global airlines expected to face a combined US$84.3 billion in losses, according to a report published on June 9.AP II stated that its plan to increase the number of available flights slots would only be effective in giving a boost to the aviation industry if airlines also increased their flight frequency and reopened routes that were closed due to low demand. State-owned airport operator PT Angkasa Pura (AP) II plans to increase the number of available flight slots and normalize its operational hours in July, as it seeks to spur the recovery of the aviation industry that has been severely impacted by the ongoing health crisis.The airport operator has set a target to make 30 percent of flight slots available at its 19 airports across the country, from the previous 10 to 20 percent made available during the COVID-19 outbreak.For example, at the country’s main airport, Soekarno-Hatta International Airport in Tangerang, Banten, it aims to make 330 of the airport’s 1,100 daily flight slots available. Low cost carrier Citilink Indonesia aims to increase its flight frequency to 168 flights per day in July, from just 100 daily flights in June, its president director Juliandra Nurtjahjo said on July 4.This figure will be increased to 200 daily flights by the fourth quarter, or around 68 percent of the Citilink’s normal traffic before the pandemic.“We are optimizing aircraft utilization while prioritizing health aspects through disinfection processes and with the use of HEPA [high-efficiency particulate air] filters,” Juliandra said.National flag carrier Garuda Indonesia, Citilink’s parent company, reported that despite a slight improvement in airline traffic in recent weeks following the easing of travel restrictions, its passenger numbers were still down 90 percent, while 70 percent of its aircraft remained grounded.The airline booked a $120 million loss in the first quarter of the year, compared to the $20.48 million profit it reaped in the January to March period of 2019.Meanwhile, AP II’s plan to normalize the airport’s operational hours was welcomed by state-owned air navigation firm AirNav Indonesia.During the pandemic, many airports across Indonesia have seen a reduction in operational hours to adjust to plummeting passenger numbers.The company will adjust its flight navigation service to the new, normalized operational hours of the airports, Airnav Indonesia president director M. Pramintohadi Sukarno said. Topics :
October 6, 2020
This luxurious home at 36 Dickson Tce in Brisbane just sold for over $10m.“Demand for truly exceptional properties in sought-after positions have outweighed the supply coming to the Brisbane market, including new builds,” she said.“Retirees continue to downsize and look for properties that offer high security while they travel abroad and low maintenance living with an array of amenities, including technology.“The prestige market is well-placed in Brisbane not only from an ageing population looking for higher amenity, but families and couples looking for prestige living well-priced when compared to other East Coast cities.” HOUSE THAT SKASE BUILT GOES FOR A SONG It comes as it was revealed the lavish Brisbane mansion built by disgraced businessman Christopher Skase has been sold for $10.138 million and Australia’s richest woman Gina Rinehart is now the owner of an $18.5 million property on the Brisbane River. GINA RINEHART SECURES $18.5M DIGS This historic Hamilton Hill home in Brisbane recently sold for just under $6m. Photo: Lyndon Mechielsen.Perth also made the list for the first time, while Sydney and Melbourne stayed in the top 10 — even though the rate of gain at the top end of the two markets slowed.Seoul topped the list, due to a near-25 per cent gain in premium property over the year to March.The overall index gained 4.8 per cent in the year to March, down slightly from December’s 4.9 per cent gain but stronger than the 4.3 per cent gain of a year earlier. Knight Frank Prime Global Cities Index, 1Q 2018. Source: Knight Frank.That rate of gain was below the 4.2 per cent recorded a year earlier, but it was enough to put the city on the international list due to changing circumstances, such as higher borrowing costs, in many global markets. Knight Frank’s Australia head of residential research Michelle Ciesielski said that while Brisbane still faced the challenge of new stock and a hangover from the end of the resources boom, the premium market was benefiting from the growing demand of downsizers looking for well-located and easy-to-maintain homes. GET THE LATEST REAL ESTATE NEWS DIRECT TO YOUR INBOX HERE More from newsParks and wildlife the new lust-haves post coronavirus19 hours agoNoosa’s best beachfront penthouse is about to hit the market19 hours ago Demand for prestige property in Brisbane is growing, according to Knight Frank.DEMAND for prestige property from cashed-up downsizers has propelled Brisbane into a global list of top-performing cities for the first time.The Queensland capital appears for the first time in the seven -year history of the Knight Frank Prime Global Cities Index, which measures the top 5 per cent of any given city’s housing market by value.Top end residential properties in Brisbane gained 3.6 per cent in the March quarter from a year earlier to place the city in 19th position.
September 24, 2020
LAUREL, Ind. – The Franklin County Sheriff’s Office is investigating a shooting that hospitalized a Laurel man Tuesday morning.Around 6:20 a.m., dispatchers received a report of a man that had been shot at the address of 110 Edgerton St. in Laurel.Officers located Dwight Jones, 59, with a gunshot wound lying inside of a pick-up truck.A 36-year-old male person of interest was detained for questioning. His identity was not immediately released.Police say they are investigating the incident as domestic violence-related, not an act of random violence.Jones was rushed to Fayette Regional Hospital before being flown to St. Vincent Hospital in Indianapolis.He is listed as stable but critical condition.
September 24, 2020
The Batesville Lady Bulldogs defeated the Switzerland County Lady Pacers at Hillcrest by a score of 183 to 261. In a Three on three match with Oldenburg the Lady Bulldogs won 125 to 167. Meredith McCreary led the Lady Bulldogs with a score of 38. Also for the Lady Bulldogs was Kelly Gole 45 Sarah Ronnebaum 42. Tori Harpring 59 Hanna Slayback 61 and Chloe Murphy 65. OA Kennedy Hannah shot 48.Courtesy of Bulldogs Coach Tom Meyer.